Bioactive Compound Characterization of Medicinal Plants in Meru Betiri National Park (Jember, Indonesia) using SPME-GCMS Analysis
DOI:
https://doi.org/10.19184/bioedu.v23i2.53711Keywords:
Bioactive compound, Medicinal plants, Meru Betiri National Park, Linalyl acetat, Caryophyllene, Patchaoli alcohol, SesquiterpenesAbstract
This research aimed to identify bioactive compounds in medicinal and aromatic plants in the Meru Betiri National Park area, specifically in the Bandealit area. The sampling of medicinal plants was carried out in June 2023. The samples were analyzed using Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry (SPME-GCMS). The results showed that the most abundant compounds were terpenoid groups, especially sesquiterpene. More than 50% of sesquiterpene compounds were detected in 10 medicinal plants in Meru Betiri National Park. Sesquiterpene compounds identified include Germacrene-D found in seven plants and Caryophyllene found in six plants. Sesquiterpene has been shown to have various pharmacological effects such as anticancer, antibacterial, anti-inflammatory, as well as antioxidant. The results of this research can be a reference for exploring the pharmacological effects of each medicinal plant in Meru Betiri National Park.
Downloads
References
Ahmed, E.A. et al. (2022) Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules. Molecules. [Online] 27 (23), MDPI. Available from: doi:10.3390/molecules27238354.
Balai Taman Nasional Meru Betiri (2022) Statistik Balai Taman Nasional Meru Betiri Tahun 2021. Jember, Kementrian Lingkungan Hidup dan Kehutanan, Direktorat Jenderal Konservasi Sumber Daya Alam dan Ekosistem.
Breitmaier, E. (2006) Terpenes : flavors, fragrances, pharmaca, pheromones. WILEY-VCH.
Cahyaningsih, R., Magos Brehm, J. & Maxted, N. (2021) Setting the priority medicinal plants for conservation in Indonesia. Genetic Resources and Crop Evolution. [Online] 68 (5), Springer Science and Business Media B.V., 2019–2050. Available from: doi:10.1007/s10722-021-01115-6.
Chen, F.Y. et al. (2021) Sesquiterpenoids with neuroprotective activities from the Chloranthaceae plant Chloranthus henryi. Fitoterapia. [Online] 151, Elsevier B.V. Available from: doi:10.1016/j.fitote.2021.104871.
Chen, X. et al. (2023a) Recent advances in biosynthesis and pharmacology of β-elemene. Phytochemistry Reviews. [Online] 22 (1), Springer Science and Business Media B.V., pp.169–186. Available from: doi:10.1007/s11101-022-09833-0.
Chen, X. et al. (2023b) Recent advances in biosynthesis and pharmacology of β-elemene. Phytochemistry Reviews. [Online] 22 (1), Springer Science and Business Media B.V., pp.169–186. Available from: doi:10.1007/s11101-022-09833-0.
Dahham, S.S. et al. (2015) The anticancer, antioxidant and antimicrobial properties of the sesquiterpene β-caryophyllene from the essential oil of Aquilaria crassna. Molecules. [Online] 20 (7), MDPI AG, 11808–11829. Available from: doi:10.3390/molecules200711808.
Dhyani, P. et al. (2022) Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies. Cancer Cell International. [Online] 22 (1), BioMed Central Ltd. Available from: doi:10.1186/s12935-022-02721-9.
Essien, E.E. et al. (2016) Essential oil constituents, anticancer and antimicrobial activity of Ficus mucoso and Casuarina equisetifolia leaves. ~ 1 ~ American Journal of Essential Oils and Natural Products. 4 (1).
Józsa, L. et al. (2022) Enhanced Antioxidant and Anti-Inflammatory Effects of Self-Nano and Microemulsifying Drug Delivery Systems Containing Curcumin. Molecules. [Online] 27 (19), MDPI. Available from: doi:10.3390/molecules27196652.
Ministry of National Development Planning, Ministry of Environment & Indonesian Institute of Sciences (2016) Indonesian Biodiversity Strategy and Action Plan 2015-2020. Indonesian Goverment.
Momin, K.Ch. et al. (2021) Aromatic plants : the technology, human welfare and beyond. Sharangi, A.B. (ed.) Chapter 6. New York, Nova Science Publishers.
Novak, J. (2020) Medicinal, Aromatic and Stimulant Plants. Bluthner, W.-D. (ed.) [Online] Switzerland, Springer Nature. Available from: http://www.springer.com/series/7290.
Nugraha, A.S. et al. (2020) Phytochemical Screening and the Antimicrobial and Antioxidant Activities of Medicinal Plants of Meru Betiri National Park–Indonesia. Journal of Herbs, Spices and Medicinal Plants. [Online] 26 (3), Taylor and Francis Inc., 303–314. Available from: doi:10.1080/10496475.2020.1734136.
Paço, A. et al. (2022) Anti-Inflammatory and Immunoregulatory Action of Sesquiterpene Lactones. Molecules. [Online] 27 (3), MDPI. Available from: doi:10.3390/molecules27031142.
Pereira, I. et al. (2018) Linalool bioactive properties and potential applicability in drug delivery systems. Colloids and Surfaces B: Biointerfaces. [Online] 171, Elsevier B.V., pp.566–578. Available from: doi:10.1016/j.colsurfb.2018.08.001.
Pinho-Da-Silva, L. et al. (2012) Trans-caryophyllene, a natural sesquiterpene, causes tracheal smooth muscle relaxation through blockade of voltage-dependent CA 2+ channels. Molecules. [Online] 17 (10), 11965–11977. Available from: doi:10.3390/molecules171011965.
Sülsen, V.P. (2021) Sesquiterpene lactones and diterpenes: Promising therapeutic candidates for infectious diseases, neoplasms and other chronic disorders. Molecules. [Online] 26 (5), MDPI AG. Available from: doi:10.3390/molecules26051251.
Thakur, M. et al. (2023) Comparative analysis of the antibacterial efficacy and bioactive components of Thuja occidentalis obtained from four different geographical sites. Molecular and Cellular Biochemistry. [Online] Springer. Available from: doi:10.1007/s11010-023-04729-9.
Wang, X.-S. et al. (2006) The Effect of d-Elemene on Hela Cell Lines by Apoptosis Induction. Yakugaku zasshi. 126 (10), 979–990.
Wang, Y.H. & Zhang, Y.R. (2020) Variations in compositions and antioxidant activities of essential oils from leaves of Luodian Blumea balsamifera from different harvest times in China. PLoS ONE. [Online] 15 (6), Public Library of Science. Available from: doi:10.1371/journal.pone.0234661.
Weaver, C.M. (2014) Bioactive foods and ingredients for health. Advances in Nutrition. [Online] 5 (3), American Society for Nutrition, 306S-311S. Available from: doi:10.3945/an.113.005124.
Williams, C. & Buica, A. (2020) Comparison of an offline SPE–GC–MS and online HS–SPME–GC–MS method for the analysis of volatile terpenoids in wine. Molecules. [Online] 25 (3), MDPI AG. Available from: doi:10.3390/molecules25030657
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Sulifah Aprilya Hariyani, Imam Mudakir, Pujiastuti, Iis Nur Asyiah, Ika Lia Novenda, Nadyatul Ilma Indah Savira
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
